Skip to main content
Pandemics

Trade: CDC issues Level 4 warning by December 31?

14% YES 86% NO

Opened · Settles

Resolution criteria on PolyGram: This market will resolve to "Yes" if the CDC issues a Level 4 (“Avoid All Travel”) Travel Health Notice for any disease by December 31, 2026, 11:59 PM ET. Otherwise, this market will resolve to "No". A Level 4 notice listed for any amount of time during this market’s timeframe will suffice for a "Yes" resolution. The primary resolution source for this market will be the CDC’s official Travel Health Notices page (https://wwwnc.cdc.gov/travel/notices); however, a consensus of credible reporting will also be used.

PolyGram is an on-chain prediction market where you trade YES or NO outcome shares with real USDC on Polygon. For this market, buy YES if you believe the event will happen, or NO if you think it won't. Your maximum loss is your stake — winning shares pay $1.00 each at resolution. Unlike sportsbooks, there is no house edge: prices are set by supply and demand from other traders and reflect the crowd's real-time probability.

Liquidity
$3K
Total Volume
$71K
24h Volume
Open Interest
$4K
Trade this market on PolyGram →

Market outcomes

CDC issues Level 4 warning by December 31? 14% YES86% NO

Market context

The CDC's Travel Health Notice system uses a four-tier classification, with Level 4 ("Avoid All Travel") representing the highest alert status reserved for destinations where disease transmission poses substantial risk to travellers. The current order book on Polymarket prices this outcome at 14% implied probability through December 2026, reflecting relatively low near-term expectations for such an escalation across the roughly two-year settlement window.

Historically, Level 4 notices have been issued sparingly. The CDC issued them during the 2014–2016 West African Ebola outbreak (Guinea, Liberia, Sierra Leone), the 2016 Zika epidemic in parts of Latin America and the Caribbean, and for Yemen during its cholera crisis. The 2020 COVID-19 pandemic prompted widespread Level 4 notices but only after sustained community transmission had already occurred globally. The rarity of these designations—typically requiring both documented sustained transmission and significant risk to international travellers—supports the current probability assessment that such a notice remains unlikely within a 24-month horizon absent a novel pathogen emergence or rapid escalation of an existing threat.

Traders monitoring this market should track WHO disease surveillance reports, emerging pathogen announcements from major health agencies, and any unusual outbreak clusters reported in credible epidemiological sources. The WHO's Disease Outbreak News feed and CDC's Emerging Infectious Diseases journal provide early signals. Seasonal influenza variants, mpox developments, and any novel zoonotic spillover events represent potential catalysts. The market's probability will likely shift materially only following confirmed sustained human-to-human transmission of a novel or significantly mutated pathogen with demonstrated travel-related spread potential.

How this market resolves

Resolution is handled by the UMA optimistic oracle on Polygon. A proposer submits the outcome, a two-hour dispute window opens, and if no one stakes a counter-claim the payout is final. Contested outcomes escalate to UMA token-holder voting. Payouts clear in USDC to the winning side.

How to trade this market step by step

The mechanics for trading "CDC issues Level 4 warning by December 31?" are the same as any other PolyGram event contract. Each YES share resolves to $1 if the event happens, or $0 if it doesn't. The current price between 0¢ and 100¢ is the market's probability estimate, set live by the order book.

  1. Sign in on polygram.ink with your email — no full KYC under $1,500 lifetime trading volume.
  2. Deposit USDC on Polygon (lowest fees, ~$0.01 per transaction) or Ethereum. Funds credit after 12 confirmations.
  3. Pick a side. Buy YES if you believe the event will happen; buy NO if you think it won't. The current YES price reflects the market's collective probability.
  4. Size your position. If you stake 100 USDC at 14% YES, you'll receive shares that pay $714 if YES resolves true — a 614% gross return. If NO resolves, your shares are worth $0.
  5. Set risk controls (optional). Stop-loss, take-profit, and limit-order types all supported. Use the trade ticket's slippage box to cap your maximum entry price.
  6. Wait for resolution. When the event resolves on-chain via the UMA optimistic oracle, the winning side settles to 100¢ automatically and USDC hits your balance within seconds. Withdrawable to any wallet you control.

How active is this market?

$71K in lifetime turnover and $3K of resting liquidity puts this market in the above the median by volume for pandemics contracts on PolyGram. Order-book depth is thin — large orders may need to be split across the book or executed as limit orders.

The market has been open for 4 months — the price has had time to stabilise as new information arrived.

Higher-volume markets tend to have tighter spreads and faster price discovery — meaning the displayed YES/NO percentages are more likely to reflect the true crowd-implied probability rather than a single trader's directional view.

Key terms

YES / NO share
A binary outcome token that pays $1.00 if the underlying claim resolves true (YES) or false (NO), and $0 otherwise. The market price between 0¢ and 100¢ is the implied probability.
CLOB
Central limit order book. The matching engine that pairs YES buyers with NO buyers (effectively the same trade). Polymarket's CLOB on Polygon executes trades on-chain via the conditional-tokens framework.
Liquidity
USDC capital sitting in resting limit orders inside the order book. Deeper liquidity means smaller slippage on large trades and a tighter bid-ask spread.
UMA optimistic oracle
The on-chain dispute system that settles each Polymarket market. A proposer submits the outcome, a two-hour challenge window opens, and unchallenged proposals finalise the resolution.
Slippage
The difference between the displayed mid-price and your fill price. Affects market orders most; limit orders avoid slippage but may take time to fill.
Conditional token
ERC-1155 outcome share issued by Gnosis Conditional Tokens on Polygon. The token type that resolves to $1.00 or $0.00 at settlement.

See the full prediction-market glossary →

Frequently asked questions

What is the current probability for "CDC issues Level 4 warning by December 31?"?

As of today, traders on Polymarket price this outcome at 14%. The number updates continuously as the order book clears. PolyGram mirrors the same live odds with locale-aware formatting and USDC settlement.

How does this market resolve?

Resolution is handled by the UMA optimistic oracle on Polygon. A proposer submits the outcome, a 2-hour dispute window opens, and if uncontested the payout is final. Contested outcomes escalate to UMA token holders.

When does this market close?

This prediction market is scheduled to close on 31 December 2026. After the resolving event occurs, settlement typically clears within 24 hours once the UMA optimistic oracle confirms the outcome. All payouts are in USDC on the Polygon network.

How can I trade on "CDC issues Level 4 warning by December 31?"?

To trade on this prediction market, create a free PolyGram account at polygram.ink, deposit USDC via Polygon, and place a YES or NO order on the outcome you believe in. You can learn more on our how-it-works page. Your maximum loss is limited to your stake — there is no leverage or margin.

What happens when the market resolves?

When the outcome is determined, winning YES shares pay out $1.00 each in USDC, while losing shares pay $0. Settlement is handled by the UMA optimistic oracle on Polygon — a proposer submits the result, a two-hour dispute window opens, and if uncontested, payouts are distributed automatically. You can withdraw your winnings to any Polygon wallet.

Risk and regulatory note

Prediction-market positions can lose 100% of staked capital. Outcomes are uncertain by definition — historical accuracy of crowd-implied probabilities is high in aggregate but not for any single market. PolyGram does not provide investment advice. Trade only with capital you can afford to lose.

Regulatory status varies by jurisdiction. Germany, the United States, and most EU countries treat Polymarket-style event contracts under one of three frameworks: financial derivative, gambling product, or unregulated novel asset. Consult local counsel before trading.

View live odds & trade →

Related prediction markets

Explore more prediction market odds and trading opportunities on PolyGram: